Two Simple, fast, accurate, precise, robust, rugged and economical UV- Spectrophotometric methods have been developed for simultaneous estimation of Montelukast Sodium (MTKT) and Desloratadine (DLOR) in combined tablet dosage form. Methanol was used as solvent. In method-I (Multicomponant mode of analysis) two wavelengths wasselected on basis ofλmax, for MTKT 283nm and DLOR244nm. MTKT and DLOR at their respective λmax show linearity in the concentration range of 18-26μg/ml and 9-13μg/ml respectively. In Method-II (First order derivative spectroscopy) absorbance was measured at 280.8nm (zero crossing point of MTKT) and 241.4nm (zero crossing point of DLOR), at these zero crossing points both drugs shows linearity in the concentration range of 8-40μg/ml and 4-20μg/ml for MTKT and DLOR respectively.The mean % recoveries were 99.99% and 100.80% in method-I and 100.42% and 100.12% in method-II for MTKT and DLOR respectively.Precision was good with acceptable limits of detection (LOD) and quantitation (LOQ) for both compounds. Percent label claim of the compounds were100.25% and 99.96% in method-I and 100.29% and 99.11% in method-II for MTKT and DLOR respectively. The optimized methods showed good reproducibility with percent relative standard deviation less then 2.0%.
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